Parenteral antibiotic formulations are sterile formulation to be administered through pierced skin to sufficient depth having advantages of free from hepatic first pass, total bioavailability and fast action but have number of major disadvantages that makes it less susceptible to patients including real/psychological pain, requirement of trained technical person for administration. In comparison to parenteral formulations; most natural, easy and safe route of administration is oral route that haves additional advantages including self-administration, patient compliance, economical. In market, a number of parenteral antibiotics (piperacillin, tazobactam, cephalothin, ceftazidime, cefotaxime, ceftriaxone, cefepime, ceftaroline, ceftobiprole, cefaloridine, cefoxitin, cefazolin) are available that are used in case of life threatening situation or severe emergency cases but does not have alternate oral formulations that can be given in post-operative recovery that will have better patient compliance, self-medication. Therefore extensive research works is needed for development of alternative oral formulations for these life-saving parenteral antibiotics.
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